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KMID : 1234420090370010049
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Korean Journal of Microbiololgy and Biotechnology
2009 Volume.37 No. 1 p.49 ~ p.54
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Rhapontigenin Production by Bioconversion and Inhibition of Melanin Synthesis
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Jeon Min
Kim Jeong-Keun
Lee Kang-Moon
Lim Young-Hee
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Abstract
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Rhapontin is the glycosylated stilbene compound, and comprising major component of rhubarb root extract. Rhapontin has been used as a raw material of skinwhitening cosmetics in Korea. Rhapontigenin, the aglycone of rhapontin, has been suggested to be more active than its glycosylated form. Therefore, the rhubarb root extract was treated with commercial enzyme, Pectinex to remove glycosylated moiety of rhapontin and rhapontigenin was prepared. The resulting material was analysed and identified as rhapontigenin by proton NMR and MALDI-Mass. Rhapontigenin exhibited tyrosinase inhibitory activity with an IC50 of 126.72 μg/mL. The tyrosinase inhibitory activity of rhapontigenin was six times higher than that of rhapontin. In melanin biosynthesis inhibition assay using Streptomyces bikiniensis, rhapontigenin showed wider inhibition zone than that of rhapontin. From these results, we expect that rhapontigenin has stronger skin whitening effect than rhapontin and has advantages in cosmetic industry.
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KEYWORD
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Rhapontigenin, tyrosinase inhibitor, melanin
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